Hypericum roeperianum bark extract suppresses breast cancer proliferation via induction of apoptosis, downregulation of PI3K/Akt/mTOR signaling cascade and reversal of EMT
Michel-Gael F. Guefack, Debojit Talukdar, Rimi Mukherjee, Subhabrata Guha, Debarpan Mitra, Depanwita Saha, Gaurav Das, François Damen, Victor Kuete, Nabendu Murmu
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BApoptosisViability assayCell cycleBiologyCell cycle checkpointCancer researchMTT assayDNA fragmentationChemistryProgrammed cell deathBiochemistryNatural Compound Pharmacology StudiesPlant-Derived Bioactive CompoundsCell death mechanisms and regulation