Synthesis and biological evaluation of mixed-ligand cyclometalated iridium(<scp>iii</scp>)–quinoline complexes
Yan Yang, Chengming Wang, Feng-Hua Pan, Qi‐Pin Qin, Qiu-Ji Xie, Chen Qing, Hong Liang
Abstract
, which is clearly higher than that of cisplatin. According to the biological assay, the cyclometalated Ir(III)-quinoline complex 2e exhibited a higher anticancer effect than 2b, which may be associated with the electronic effect of the methyl group of the 1e ligand of 2e playing a key role in the mechanism.
Topics & Concepts
IridiumQuinolineLigand (biochemistry)ChemistryCombinatorial chemistryOrganic chemistryBiochemistryCatalysisReceptorMetal complexes synthesis and propertiesSynthesis and Biological EvaluationLanthanide and Transition Metal Complexes