Dynamic SUMOylation of MORC2 orchestrates chromatin remodelling and DNA repair in response to DNA damage and drives chemoresistance in breast cancer
Fanglin Zhang, Shao‐Ying Yang, Li Liao, Tai‐Mei Zhang, Yinling Zhang, Shu‐Yuan Hu, Ling Deng, Min-Ying Huang, Lisa Andriani, Xiao-Yan Ma, Zhimin Shao, Da‐Qiang Li
Abstract
Collectively, these findings uncover a novel regulatory mechanism of MORC2 by SUMOylation and reveal the intricate dynamics of MORC2 SUMOylation important for proper DDR. We also propose a promising strategy to sensitize MORC2-driven breast tumors to chemotherapeutic drugs by inhibition of the SUMO pathway.
Topics & Concepts
SUMO proteinChromatinDNA damageZinc fingerCell biologyChromatin remodelingUbiquitin ligaseUbiquitinDNA repairBiologyCancer researchChemistryDNATranscription factorBiochemistryGeneUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysCell death mechanisms and regulation