Construction of a Protoberberine Alkaloid Skeleton via the Palladium-Catalyzed α-Arylation–Amide Formation Cascade
Shaofeng Li, Hanyu Nie, Mengyan Duan, Wenfei Wang, Congjun Zhu, Chuanjun Song
Abstract
In this work, we report the strategy of one-pot synthesis of protoberberine alkaloid derivatives via palladium-catalyzed cascade α-arylation and cyclization, which can afford the target molecules in moderate to excellent isolated yields using commercially available raw materials under solvent-free conditions. This protocol provides an efficient and convenient path to multisubstituted protoberberine derivatives. In addition, it can directly afford natural alkaloids.
Topics & Concepts
ChemistryPalladiumCascadeAmideAlkaloidCatalysisCombinatorial chemistryMoleculeOrganic chemistryChromatographyCatalytic C–H Functionalization MethodsBerberine and alkaloids researchChemical synthesis and alkaloids