Association of methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms (C677T and A1298C) with thyroid dysfunction: A meta-analysis and trial sequential analysis
Yang Rui, Danhua Pu, Rongrong Tan, Jie Wu
Abstract
Recent studies have shown that two common methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms (C677T and A1298C) might correlate with thyroid dysfunction, but the results remain inconsistent. We carried out a meta-analysis aiming to assess the relationship of both polymorphisms with thyroid dysfunction. The PubMed, EMBASE, CNKI (China National Knowledge Infrastructure), CBMdisc (China Biology Medicine disc), WeiPu and Wanfang databases were searched up to September 2021. Case-control and cohort studies on MTHFR polymorphism and thyroid dysfunction were identified. Eight [...]
Topics & Concepts
Methylenetetrahydrofolate reductaseMedicineMeta-analysisThyroid dysfunctionInternal medicineSubgroup analysisSingle-nucleotide polymorphismGeneBioinformaticsOncologyThyroidGeneticsAlleleGenotypeBiologyFolate and B Vitamins ResearchIron Metabolism and DisordersPregnancy and preeclampsia studies