Mild inflammation impairs acute intermittent hypoxia-induced phrenic long-term facilitation by a spinal adenosine-dependent mechanism
Alexandria B. Marciante, Gordon S. Mitchell
Abstract
Mild inflammation undermines motor plasticity elicited by mAIH. In a model of mAIH-induced respiratory motor plasticity (phrenic long-term facilitation; pLTF), we report that inflammation induced by low-dose lipopolysaccharide undermines mAIH-induced pLTF by a mechanism requiring increased cervical spinal adenosine and adenosine 2 A receptor activation. This finding advances the understanding of mechanisms impairing neuroplasticity, potentially undermining the ability to compensate for the onset of lung/neural injury or to harness mAIH as a therapeutic modality.
Topics & Concepts
AdenosineFacilitationIntermittent hypoxiaNeuroplasticityInflammationNeuroscienceHypoxia (environmental)MedicinePhrenic nerveMechanism (biology)Respiratory systemAnesthesiaPsychologyChemistryImmunologyInternal medicineEpistemologyPhilosophyObstructive sleep apneaOrganic chemistryOxygenNeuroscience of respiration and sleepNeonatal Respiratory Health ResearchNeonatal and fetal brain pathology