Exploring the potential of polymers: advancements in oral nanocarrier technology
Rousilândia de Araujo Silva, Igor Eduardo Silva Arruda, Luíse Lopes Chaves, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho
Abstract
Polymers play a pivotal role in various drug delivery systems due to their versatility, with polymeric nanoparticles showing significant potential to overcome physiological barriers associated with oral administration. This review examines the current advancements in the application of polymers as oral nanocarriers, emphasizing key natural and synthetic polymers that enhance stability, bioavailability, and release. The physicochemical properties, biodegradability, and chemical modifications of these polymers, which promote mucoadhesion and epithelial permeability, critical factors for effective oral drug delivery, are discussed in detail. Furthermore, nanoparticle synthesis methods that enable controlled release profiles, optimized biodistribution, and improved therapeutic efficacy are also explored. Thus, polymers represent a dynamic platform for developing diverse nanocarriers for oral applications, and this review provides a valuable theoretical foundation for understanding the strategies currently employed in this field.