Takotsubo cardiomyopathy
Anthony Matta, Clément Delmas, Francesco Campelo-Parada, Thibault Lhermusier, Frédéric Bouisset, Meyer Elbaz, Vanessa Nader, Stéphanie Blanco, Jérôme Roncalli, Didier Carrié
Abstract
Takotsubo cardiomyopathy (TTC) is a clinical condition of transient acute heart failure correlated to regional wall motion abnormalities extending beyond the distribution of a single epicardial coronary artery. It is classified into four major types: apical, basal, mid-ventricular and focal. Sympathetic nerve stimulation and catecholamine storm are the main players in the pathogenesis of TTC. The clinical course of disease is generally benign but it may end with life-threatening complications. Coronary angiography, left ventriculogram, transthoracic echocardiography and cardiac magnetic resonance imaging (CMR) are the main tools for making diagnosis. Except for critical cases with hemodynamic instability and/or complications, the overall management is limited to conventional heart failure therapy.