Silencing long non-coding RNA MIAT ameliorates myocardial dysfunction induced by myocardial infarction via MIAT/miR-10a-5p/EGR2 axis
Xiangke Cao, Qinghua Ma, Bin Wang, Qingqiang Qian, Ning Liu, Tiejun Liu, Xiaoliu Dong
Abstract
experimentation also suggested that overexpression of miR-10a-5p or silencing of MIAT and EGR2 reduced cardiomyocyte apoptosis and increased ATP content, thus alleviating the impairment of cardiac function following MI. In a word, inhibition of MIAT protects against cardiac dysfunction induced by MI through the crosstalk with miR-10a-5p/EGR2.
Topics & Concepts
Long non-coding RNAGene silencingMyocardial infarctionCardiologyInternal medicineMedicineRNABiologyGeneticsGeneCancer-related molecular mechanisms researchCircular RNAs in diseasesMicroRNA in disease regulation