Interaction between Cervical Microbiota and Host Gene Regulation in Caesarean Section Scar Diverticulum
Xing Yang, Xinyi Pan, Manchao Li, Zhi Zeng, Yanxian Guo, Panyu Chen, Panyu Chen, Xiaoyan Liang, Peigen Chen, Peigen Chen, Guihua Liu
Abstract
Cesarean section scar diverticulum (CSD) has become a formidable obstacle preventing women receiving CS from reproducing. In this study, we revealed that potentially harmful microbes do have adverse effects on the host endometrium. The mechanism of these adverse effects includes the inhibition of the activity of beneficial bacteria such as lactobacilli, consumption of protective metabolites of the endometrium, and also the production of harmful metabolites. In the present study, we elucidated the mechanism from the perspectives of microbial, metabolic, and host responses, providing an important rationale to design preventive and therapeutic strategies for CSD.