Rhodium‐Catalyzed C8‐Alkenylation of Isoquinolones with Maleimides
XXXXXXX Manisha, Devesh Chandra, Upendra Sharma
Abstract
Abstract An efficient Rh(III)‐catalyzed C−H alkenylation of N ‐protected isoquinolone with maleimides is reported. The carbonyl group of isoquinolone acts as an inherent directing group. Various N ‐substituents in the maleimide, including alkyl, aryl, and even H and −OH, were well tolerated under the developed reaction condition. This protocol showed broad substrate scope, good selectivity, and excellent yields. Hammett plot is also drawn to check the effect of substituents on the reaction progress.
Topics & Concepts
ChemistryMaleimideRhodiumAlkylArylCatalysisSubstrate (aquarium)SelectivityFunctional groupReaction conditionsMedicinal chemistryCombinatorial chemistryOrganic chemistryGeologyOceanographyPolymerCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Cross-Coupling Reactions