Green synthesis, structural analysis and anticancer activity of dihydropyrimidinone derivatives
Jayanta Dowarah, Devanshi Patel, Brilliant N. Marak, Umesh C. S. Yadav, Pramod Kumar Shah, P. K. Shukla, Ved Prakash Singh
Abstract
cellular studies revealed that compounds with a chloro-group at the 3- or 4-position in the substituted ring of DHPM induced significant cell death in human A549 lung adenocarcinoma cells. This result indicates that a deactivating group (chlorine) at the 3- or 4-position in the substituted ring of DHPM might be a promising anticancer drug candidate for treating different types of cancers, particularly cancer of the lung.
Topics & Concepts
ChemistryIn silicoA549 cellRing (chemistry)StereochemistryLead compoundIn vitroEnzymeBiochemistryOrganic chemistryGeneMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis of Organic Compounds