Hybrid theranostic microbubbles for ultrasound/photoacoustic imaging guided starvation/low-temperature photothermal/hypoxia-activated synergistic cancer therapy
Feng Tian, Xingjian Zhong, Junkai Zhao, Yutian Gu, Yadi Fan, Fan Shi, Yu Zhang, Youhua Tan, Wen Chen, Changqing Yi, Mo Yang
Abstract
and exacerbated the hypoxia environment, thereby activating the toxicity of TPZ in the tumor site. Through dual-modality US/PA imaging monitoring, PDA-PVAMBs@GOx with long-term retention (∼7 days) combined with PTT and TPZ significantly inhibited the growth of solid tumors with minimum systemic side effects, which might be a powerful tool for effective tumor treatment.
Topics & Concepts
Photothermal therapyMicrobubblesTumor hypoxiaMaterials scienceHypoxia (environmental)Radiation therapyGlucose oxidaseTirapazamineBiomedical engineeringChemistryNanotechnologyUltrasoundCancer researchMedicineOxygenBiosensorRadiologyBiochemistryOrganic chemistryCytotoxicityIn vitroNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic ImagingPhotodynamic Therapy Research Studies