EPZ015666, a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an antitumour effect in retinoblastoma
Xing Liu, Jianzhong He, Longbing Mao, Yanyan Zhang, Wenwen Cui, Sujuan Duan, Alan Jiang, Yang Gao, Yi Sang, Guofu Huang
Topics & Concepts
Protein arginine methyltransferase 5RetinoblastomaRetinoblastoma proteinCancer researchCell cycleCell growthMethyltransferaseCell cycle checkpointArginineBiologyChemistryCellBiochemistryMethylationAmino acidGeneCancer-related gene regulationEpigenetics and DNA MethylationProtein Degradation and Inhibitors