Enhanced skin penetration of berberine from proniosome gel attenuates pain and inflammation in a mouse model of osteoarthritis
Choon Keong Lee, Shipin Zhang, Gopalakrishnan Venkatesan, Irsan Irsan, Suet Yen Chong, Jiong‐Wei Wang, Wei Jiang Goh, Tomasz Pańczyk, Yi Zhen Tay, Jun Hu, Wai Kiong Ng, Matthias G. Wacker, Wei Seong Toh, Giorgia Pastorin
Abstract
) on skin keratinocytes. In a mouse model of OA, the optimized formulation is able to attenuate inflammation and pain and minimize cartilage degeneration. Taken together, these data demonstrate the feasibility of adopting proniosome gels as a suitable platform to deliver active molecules for the management of osteoarthritis.
Topics & Concepts
BerberineChemistryOsteoarthritisIn vivoSorbitanTransdermalCartilagePharmacologyGlycosaminoglycanEx vivoIn vitroChromatographyBiochemistryMedicineAnatomyPathologyBiologyBiotechnologyAlternative medicineFatty acid esterFatty acidBerberine and alkaloids researchAdvancements in Transdermal Drug DeliveryBiochemical and Structural Characterization