A protein coupling and molecular simulation analysis of the clinical mutants of androgen receptor revealed a higher binding for Leupaxin, to increase the prostate cancer invasion and motility
Abbas Khan, Wenfeng Li, Amna Ambreen, Dong‐Qing Wei, Yanjing Wang, Yuanshen Mao
Topics & Concepts
Androgen receptorMolecular dynamicsCoactivatorHydrogen bondDocking (animal)Prostate cancerChemistryMutantDissociation constantBinding energyBinding selectivityBinding domainBiophysicsReceptorBinding siteBiologyCrystallographyTranscription factorBiochemistryCancerComputational chemistryGeneticsMedicinePhysicsGeneMoleculeOrganic chemistryNuclear physicsNursingMass Spectrometry Techniques and ApplicationsProtein Structure and DynamicsEstrogen and related hormone effects