SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis
Ho Sun Jung, Gene Uenishi, Mi Ae Park, Peng Liu, Kran Suknuntha, Matthew Raymond, Yoon Jung Choi, James A. Thomson, Irene M. Ong, Igor I. Slukvin
Abstract
phenotype resembling arterial HE at the sites of HSC emergence. Along with the activation of NOTCH signaling, SOX17 directly activates CDX2 expression, leading to the upregulation of the HOXA cluster genes. Since deficiencies in HOXA and NOTCH signaling contribute to the impaired in vivo engraftment of hPSC-derived hematopoietic cells, the identification of SOX17 as a key regulator linking arterial and HOXA programs in HE may help to program HSC fate from hPSCs.
Topics & Concepts
HaematopoiesisRegulatorInduced pluripotent stem cellNotch signaling pathwayStem cellBiologyCXCR4Cell biologyMyeloidRUNX1PhenotypeCancer researchEmbryonic stem cellImmunologyGeneticsSignal transductionGeneImmune systemChemokineZebrafish Biomedical Research ApplicationsCongenital heart defects researchRenal and related cancers