Osteoblast-derived EGFL6 couples angiogenesis to osteogenesis during bone repair
Kai Chen, Shijie Liao, Yicheng Li, Haibo Jiang, Yun Liu, Chao Wang, Vincent Kuek, Jacob Kenny, Boxiang Li, Qian Huang, Jian-Xin Hong, Yan Huang, Shek Man Chim, Jennifer Tickner, Nathan J. Pavlos, Jinmin Zhao, Qian Liu, An Qin, Jiake Xu
Abstract
Together, these data demonstrate that EGFL6 serves as an essential regulator to couple osteogenesis to angiogenesis during bone repair.
Topics & Concepts
OsteoblastCell biologyAngiogenesisRUNX2Bone morphogenetic protein 2Mesenchymal stem cellBone healingBone morphogenetic proteinSMADChemistryBiologySignal transductionCancer researchIn vitroAnatomyBiochemistryGeneTGF-β signaling in diseasesBone health and treatmentsBone Metabolism and Diseases