Change in hospital antibiotic use and acquisition of multidrug-resistant gram-negative organisms after the onset of coronavirus disease 2019
Jacqueline Bork, Surbhi Leekha, Kimberly C. Claeys, Hyunuk Seung, Megan Tripoli, Anthony Amoroso, Emily L. Heil
Abstract
Interrupted time series segmented regression was conducted to trend antibiotic use and multidrug-resistant gram-negative (MDRGN) acquisition relative to COVID-19 in an academic hospital. Total antibiotic use and antibiotic use related to pneumonia was higher in the period after the onset of COVID-19 compared to the similar calendar period in 2019. Furthermore, MDRGN acquisition increased 3% for every increase in positive COVID-19 tests per week.
Topics & Concepts
AntibioticsGramPneumoniaCoronavirus disease 2019 (COVID-19)MedicineMultiple drug resistanceDiseaseInternal medicineBiologyMicrobiologyInfectious disease (medical specialty)BacteriaGeneticsAntibiotic Use and ResistanceAntibiotics Pharmacokinetics and EfficacyAntibiotic Resistance in Bacteria