A novel multifunctional FePt/BP nanoplatform for synergistic photothermal/photodynamic/chemodynamic cancer therapies and photothermally-enhanced immunotherapy
Xiuxiu Yao, Baochan Yang, Shan Wang, Zhichao Dai, Dongsheng Zhang, Xiuwen Zheng, Qingyun Liu
Abstract
into reactive oxygen species (ROS) through the Fenton reaction, ultimately inducing cell death. Based on magnetic resonance imaging (MR) and thermal imaging, the as-prepared FePt/BP-PEI-FA NCs can inhibit tumor growth by achieving synergistic therapies. More significantly, combined with cytotoxic T lymphocyte-associated protein 4 (CTLA-4) checkpoint blockade, FePt/BP-PEI-FA NC-induced PTT can control both primary and untreated distant tumors' growth. Therefore, FePt/BP-PEI-FA NCs is a potential multifunctional nanoagent for effective anti-tumor applications.
Topics & Concepts
Photothermal therapyImmunotherapyPhotodynamic therapyCancerCancer researchMaterials scienceCancer immunotherapyMedicineNanotechnologyChemistryInternal medicineOrganic chemistryNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisGold and Silver Nanoparticles Synthesis and Applications