Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease
Farida Benhadou, Elisabeth Glitzner, Audrey Brisebarre, Benjamin Swedlund, Yura Song, Christine Dubois, Milena Rozzi, Catherine Paulissen, V. del Mármol, Maria Sibilia, Cédric Blanpain
Abstract
overexpression in keratinocytes. In conclusion, our study identifies an epidermal autonomous function of Vegfa/Nrp1/Flt1 that mediates psoriatic-like disease and demonstrates the clinical relevance of blocking Vegfa/Nrp1/Flt1 axis in psoriasis.
Topics & Concepts
PsoriasisVascular endothelial growth factor AAngiogenesisCancer researchNeuropilin 1BiologyImmunologyVascular endothelial growth factorVEGF receptorsPsoriasis: Treatment and PathogenesisCytokine Signaling Pathways and InteractionsDermatology and Skin Diseases