A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers
Romualdo Troisi, Claudia Riccardi, Kévan Pérez de Carvasal, Michaël Smietana, F. Morvan, Pompea Del Vecchio, Daniela Montesarchio, Filomena Sica
Abstract
-cyclic charge-transfer structure in nucleic acid-based ligands to improve the interactions with proteins, thus considerably widening their potentialities.
Topics & Concepts
AptamerOligonucleotideThrombinChemistryCombinatorial chemistryStereochemistryBiochemistryDNABiologyMolecular biologyImmunologyPlateletAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRNA Interference and Gene Delivery