A unified strategy to prostaglandins: chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGF<sub>2α</sub>, fluprostenol, and travoprost guided by biocatalytic retrosynthesis
Kejie Zhu, Meifen Jiang, Baijun Ye, Guotai Zhang, Weijian Li, Pei Tang, Zedu Huang, Fen‐Er Chen
Abstract
We report a unified chemoenzymatic asymmetric synthesis of five prostaglandins, featuring two enzymatic redox transformations and a copper(<sc>ii</sc>)-catalyzed regioselective <italic>p</italic>-phenylbenzoylation.
Topics & Concepts
BimatoprostTravoprostRegioselectivityCloprostenolChemistryStereochemistryCombinatorial chemistryOrganic chemistryCatalysisBiochemistryBiologyNeuroscienceOcular hypertensionOvulationGlaucomaHormoneEnzyme Catalysis and ImmobilizationSteroid Chemistry and BiochemistrySynthesis and Catalytic Reactions