Phenotypic and Functional Characteristics of a Novel Influenza Virus Hemagglutinin-Specific Memory NK Cell
Jian Zheng, Liyan Wen, Hui‐Ling Yen, Ming Liu, Yinping Liu, Ooiean Teng, Wing-Fung Wu, Ke Ni, Kowk-Tai Lam, Chunyu Huang, Jiashuang Yang, YL Lau, Stanley Perlman, Malik Peiris, Wenwei Tu
Abstract
In this study, we demonstrate a novel hemagglutinin (HA)-specific NKp46 + NKG2A + NK cell subset induced by influenza A virus infection. These memory NK cells show virus-specific decreased cytotoxicity and increased gamma interferon (IFN-γ) on reencountering the same influenza virus antigen. In addition, they modulate host recall responses and CD8 T cell distribution, thus bridging the innate immune and adaptive immune responses during influenza virus infection.
Topics & Concepts
BiologyHemagglutinin (influenza)VirusVirologyImmune systemInfluenza A virusInterferonImmunologyPhenotypeGeneBiochemistryImmune Cell Function and InteractionInfluenza Virus Research StudiesRespiratory viral infections research