Absolute Configuration Assignment to Chiral Natural Products by Biphenyl Chiroptical Probes: The Case of the Phytotoxins Colletochlorin A and Agropyrenol
Ernesto Santoro, Stefania Vergura, Patrizia Scafato, Sandra Belviso, Marco Masi, Antonio Evidente, Stefano Superchi
Abstract
). Moreover, with the biphenyl method the configurational assignment can be obtained simply by the sign of a diagnostic Cotton effect at 250 nm in the ECD spectrum, thus allowing application without the need of advanced knowledge of chiroptical spectroscopy and computational protocols.
Topics & Concepts
Absolute configurationBiphenylPhytotoxinChemistryEnantiomerStereochemistrySign (mathematics)Circular dichroismSpectroscopyOrganic chemistryPhysicsMathematicsToxinBiochemistryMathematical analysisQuantum mechanicsMolecular spectroscopy and chiralityAnalytical Chemistry and ChromatographyAxial and Atropisomeric Chirality Synthesis