Human Mesenchymal Stem Cell Therapy and Other Novel Treatment Approaches for Premature Ovarian Insufficiency
Mara Ulin, Esra Çetin, Elie Hobeika, Rishi Man Chugh, Hang-Soo Park, Sahar Esfandyari, Ayman Al‐Hendy
Abstract
Premature ovarian insufficiency (POI) is a condition characterized by amenorrhea, hypergonadotropic hypogonadism, estrogen deficiency, and reduced follicle counts leading to infertility under the age of 40. POI occurs in approximately 1-3% of women in the general population. Evaluation is warranted when the diagnosis of POI is made to rule out underlying etiologies, which could be multifactorial. This review serves to cover the novel treatment approaches reported in the literature.
Topics & Concepts
Premature ovarian insufficiencyHypergonadotropic hypogonadismInfertilityPremature ovarian failureMedicineEtiologyReproductive medicineAmenorrheaGynecologyPopulationStem cellPediatricsPregnancyBioinformaticsInternal medicineBiologyHormoneEnvironmental healthGeneticsReproductive Biology and FertilityTissue Engineering and Regenerative MedicineSperm and Testicular Function