<i>parC</i> Variants in Mycoplasma genitalium: Trends over Time and Association with Moxifloxacin Failure
Gerald L. Murray, Kaveesha Bodiyabadu, Lenka A. Vodstrcil, Dorothy A. Machalek, Jennifer Danielewski, Erica L. Plummer, Suzanne M. Garland, David M. Whiley, Emma L. Sweeney, Catriona S. Bradshaw
Abstract
= 0.046). From 381 moxifloxacin treatments, failure occurred in 58.7% (95% confidence interval [CI], 46.7 to 69.9) of cases with S83I. Other changes affecting S83 or D87 were uncommon and minor contributors to failure. The absence of S83I was highly predictive of moxifloxacin cure (96.4%; 95% CI, 93.7 to 98.2), highlighting diagnostic potential.
Topics & Concepts
MoxifloxacinMycoplasma genitaliumMicrobiologyVirologyBiologyMedicineGeneticsAntibioticsChlamydia trachomatisReproductive tract infections researchBlood groups and transfusionMicrobial infections and disease research