GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17
Subbroto Kumar Saha, Hye Yeon Choi, Gwang‐Mo Yang, Polash Kumar Biswas, Kyeongseok Kim, Geun‐Ho Kang, Minchan Gil, Ssang‐Goo Cho
Abstract
silencing also downregulated transcription and translation of ADAM17 through the AKT/specificity protein-1 (SP1) signaling axis. Notably, GPR50 was found to directly interact with ADAM17. Overall, we demonstrate a novel GPR50-mediated regulation of the ADAM17-Notch signaling pathway, which can provide insights into HCC progression and prognosis and development of Notch-based HCC treatment strategies.
Topics & Concepts
Hepatocellular carcinomaNotch signaling pathwayCancer researchSignal transductionCell biologyMedicineBiologyCancer-related gene regulationHistone Deacetylase Inhibitors ResearchEpigenetics and DNA Methylation