Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP)
Joseph D. Ho, Matthew R. Lee, Charles T. Rauch, Kristen Aznavour, Jonathan S. Park, J.G. Luz, Stephen Antonysamy, Bradley Condon, Milan Maletic, Aiping Zhang, Michael J. Hickey, Norman E. Hughes, Srinivasan Chandrasekhar, Ashley V. Sloan, Karen M. Gooding, Anita K. Harvey, Xiaopeng Yu, Steven D. Kahl, Bryan H. Norman
Topics & Concepts
Drug discoveryPharmacophoreEicosanoidChemistryTarget proteinLigand (biochemistry)DrugIn vitroLipoxygenaseProstaglandinLeukotrieneBiochemistryEnzymeComputational biologyPharmacologyReceptorBiologyArachidonic acidGeneAsthmaImmunologyInflammatory mediators and NSAID effectsAsthma and respiratory diseasesEicosanoids and Hypertension Pharmacology