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Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment

William D. Green, Amber Gomez, Alec L. Plotkin, Brandon M. Pratt, Emily F. Merritt, Genevieve N. Mullins, Nancy P. Kren, Jennifer L. Modliszewski, Vasyl Zhabotynsky, Mark G. Woodcock, Jarred M Green, Gabrielle Cannon, Matthew E. Pipkin, Gianpietro Dotti, Jessica E. Thaxton, Yuliya Pylayeva‐Gupta, Albert S. Baldwin, John P. Morris, Natalie Stanley, J. Justin Milner

2025Immunity23 citationsDOIOpen Access PDF

Topics & Concepts

EnhancerBiologyTranscription factorCell biologyAdaptation (eye)GeneGene regulatory networkTranscription (linguistics)Regulation of gene expressionCancer researchTumor microenvironmentGeneticsComputational biologyGene expressionTumor cellsNeuroscienceLinguisticsPhilosophySingle-cell and spatial transcriptomicsCAR-T cell therapy researchT-cell and B-cell Immunology
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment | Litcius