Dealkenylative Ni-Catalyzed Cross-Coupling Enabled by Tetrazine and Photoexcitation
Si‐Cong Chen, Qi Zhu, Yuhui Cao, Chen Li, Yinliang Guo, Lingran Kong, Jin−Teng Che, Zhixian Guo, Han Chen, Nan Zhang, Xianhe Fang, Jia‐Tian Lu, Tuoping Luo
Abstract
A new and general method to functionalize the C(sp3)–C(sp2) bond of alkyl and alkene linkages has been developed, leading to the dealkenylative generation of carbon-centered radicals that can be intercepted to undergo Ni-catalyzed C(sp3)–C(sp2) cross-coupling. This one-pot protocol leverages the easily procured alkene feedstocks for organic synthesis with excellent functional group compatibility without the need for a photoredox catalyst.
Topics & Concepts
ChemistryAlkeneTetrazineCatalysisPhotoexcitationRadicalFunctional groupCombinatorial chemistryPhotoredox catalysisPhotochemistryOrganic chemistryExcitationPolymerPhotocatalysisEngineeringElectrical engineeringRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques