Supramolecular multivalency effects enhance imine formation in aqueous medium allowing for dynamic modification of enzymatic activity
Ferran Esteve, Fidan Rahmatova, Jean‐Maríe Lehn
Abstract
Supramolecular multivalent effects increase the stability of aldimines under physiological conditions. This approach was used for the dynamic inhibition of carbonic anhydrase, recovering its initial activity in the presence of a chemical scavenger.
Topics & Concepts
ImineSupramolecular chemistryChemistryAqueous solutionAqueous mediumCombinatorial chemistryEnzymeOrganic chemistryMoleculeCatalysisChemical Synthesis and AnalysisAmino Acid Enzymes and MetabolismEnzyme Catalysis and Immobilization