SARS‐CoV‐2 induced post‐translational protein modifications: A trigger for developing autoimmune diabetes?
Chaplin Catriona, Pozzilli Paolo
Abstract
Emerging evidence indicates a bi-directional relationship between SARS-CoV-2 and diabetes. The possibility exists that SARS-CoV-2 could induce diabetes, but it is not yet clear whether this might be a fulminant-type diabetes, autoimmune diabetes, or a new-onset transient hyperglycaemia. This viewpoint discusses mechanisms by which SARS-CoV-2 might trigger type 1 diabetes mellitus (T1DM). Specifically, we looked at the role of post-translational protein modifications (PTMs) and the generation of neoepitopes as a potential mechanism in the induction of islet autoimmunity, and the pathways via which coronavirus infections might exacerbate the formation of PTMs and, in so doing, provoke the onset of T1DM.
Topics & Concepts
Mechanism (biology)ImmunologyMedicineAutoimmune diseaseAutoimmunityType 1 diabetesCoronavirusDiabetes mellitusImmune systemSignal transductionIsletAutoantibodyDiseaseSelf ToleranceBiologyCell biologyUnfolded protein responseExosome complexType 2 Diabetes MellitusAntibodyImmunityDiabetes and associated disordersSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies