Application of Copper Iodide Nanoparticle-Doped Film and Fabric To Inactivate SARS-CoV-2 via the Virucidal Activity of Cuprous Ions (Cu <sup>+</sup> )
Yohei Takeda, Dulamjav Jamsransuren, Tomokazu Nagao, Yoko Fukui, Sachiko Matsuda, Haruko Ogawa
Abstract
. Our results showed that the CuI dispersion, as well as CuI-doped film and fabric, rapidly inactivated SARS-CoV-2 with a high viral titer. We also demonstrated the CuI's virucidal mechanisms of action, specifically the destruction of viral proteins and the genome by CuI treatment. Protein destruction largely depended on CuI-derived reactive oxygen species. This study provides novel information about the utility and mechanisms of action of promising virucidal material against SARS-CoV-2.
Topics & Concepts
IodideMode of actionChemistryMicrobiologyTiterCopperVirologyCoronavirusSevere acute respiratory syndrome coronavirusReactive oxygen speciesNanoparticleBacteriaBlotSuppressorCoronavirus disease 2019 (COVID-19)VaccinationVirusHighly pathogenicViral loadMechanism of actionPandemicBiologySensitizationViral proteinVirulenceViral infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)IonSARS-CoV-2 detection and testingGraphene and Nanomaterials ApplicationsNanoparticles: synthesis and applications