Rational design, synthesis and biological evaluation of novel 2-(substituted amino)-[1,2,4]triazolo[1,5-a]pyrimidines as novel tubulin polymerization inhibitors
Lin Chen, Tangyang Ji, Xian‐Sen Huo, Zhiyu Zeng, Wei-Xuan Ye, Chenchen Dai, Yuqi Zhang, Wen‐Wei You, Pei‐Liang Zhao
Topics & Concepts
HeLaChemistryTubulinIC50StereochemistryPolymerizationStructure–activity relationshipMicrotubuleSelectivityApoptosisIn vitroCombinatorial chemistryBiochemistryOrganic chemistryPolymerCatalysisBiologyCell biologySynthesis and biological activityClick Chemistry and ApplicationsQuinazolinone synthesis and applications