Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
Liang Chen, Biyun Zhu, Gaomeng Ru, Haowei Meng, Yongchang Yan, Mengjia Hong, Dan Zhang, Changming Luan, Shun Zhang, Hao Wu, Hongyi Gao, Sijia Bai, Changqing Li, Ruoyi Ding, Niannian Xue, Zhi‐Xin Lei, Yuting Chen, Yuting Guan, Stefan Siwko, Yiyun Cheng, Gaojie Song, Liren Wang, Chengqi Yi, Mingyao Liu, Dali Li
Topics & Concepts
Cytosine deaminaseCytosineCytidine deaminaseActivation-induced (cytidine) deaminaseIndelAPOBECChemistryCRISPRCytidineCas9UracilBiochemistryDNA glycosylaseThymineDNABiologyEnzymeGeneGeneticsDNA repairGenomeGenetic enhancementImmunoglobulin class switchingAntibodySingle-nucleotide polymorphismB cellGenotypeCRISPR and Genetic EngineeringRNA regulation and diseaseViral Infections and Immunology Research