Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs
Ana Ortega-Molina, Cristina Lebrero‐Fernández, Alba Sanz, Nerea Deleyto-Seldas, Ana Belén Plata-Gómez, Camino Menéndez, Osvaldo Graña‐Castro, Eduardo Caleiras, Alejo Efeyan
Abstract
mice show normal longevity and normal age-dependent health decline. These results support the efficacy and safety of moderate inhibition of nutrient signaling against pathological B cells.
Topics & Concepts
BiologyGTPasePhenotypeCell biologySignal transductionCancer researchSmall GTPaseAutoimmunityCellCell signalingImmunologyGeneImmune systemGeneticsT-cell and B-cell ImmunologyPI3K/AKT/mTOR signaling in cancerImmune Cell Function and Interaction