Learning from natural variation across the proteomes of single cells

Abstract

We normally think of experiments as procedures carefully designed by scientists and engineers. However, some of the best experiments arise from natural processes. For example, evolution and gene segregation during reproduction can be seen as natural experiments that have revealed much about protein functions and about genetic associations with diseases A salient advantage of such natural experiments is that they provide empirical evidence that is inaccessible to human designed experiments because of ethical and technical limitations.

Topics & Concepts