Generation of hypoxia-sensing chimeric antigen receptor T cells
Paris Kosti, Karen I. Larios-Martinez, John Maher, James N. Arnold
Abstract
preclinical characterization. For complete details on the use and execution of this protocol, please refer to Kosti et al. (2021).
Topics & Concepts
Chimeric antigen receptorHypoxia (environmental)In vivoIn vitroChimera (genetics)AntigenCancer researchReceptorCell biologyTumor microenvironmentBiologyChemistryImmunologyImmunotherapyTumor cellsImmune systemOxygenGeneBiochemistryBiotechnologyOrganic chemistryCAR-T cell therapy researchImmune Cell Function and InteractionNeuroblastoma Research and Treatments