Construction of α-Amino Azines via Thianthrenation-Enabled Photocatalyzed Hydroarylation of Azine-Substituted Enamides with Arenes
Yulan Zhang, Ganghu Wang, Yichen Wu, Chunyin Zhu, Peng Wang
Abstract
α-Amino azines are widely found in pharmaceuticals and ligands. Herein, we report a practical method for accessing this class of compounds via photocatalyzed hydroarylation of azine-substituted enamides with the in situ-generated aryl thianthrenium salts as the radical precursor. This reaction features a broad substrate scope, good functional group tolerance, and mild conditions and is suitable for the late-stage installation of α-amino azines in complex structures.
Topics & Concepts
AzineChemistryCombinatorial chemistrySubstrate (aquarium)Functional groupArylOrganic chemistryGeologyAlkylPolymerOceanographyCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesRadical Photochemical Reactions