Potential G-Quadruplex Forming Sequences and <i>N</i> <sup>6</sup> -Methyladenosine Colocalize at Human Pre-mRNA Intron Splice Sites
Manuel Jara‐Espejo, Aaron M. Fleming, Cynthia J. Burrows
Abstract
A. These bioinformatic analyses guide a discussion of future experiments to understand how noncanonical rG4 structures may collaborate with epitranscriptomic modifications in the human cellular context to impact cellular phenotype.
Topics & Concepts
IntronBiologyRNA splicingColocalizationContext (archaeology)RNAN6-MethyladenosineMessenger RNAGeneticsAlternative splicingPseudouridineCell biologyGeneTransfer RNAMethylationMethyltransferasePaleontologyRNA modifications and cancerRNA Research and SplicingRNA and protein synthesis mechanisms