Colonization of the Murine Oropharynx by Streptococcus pyogenes Is Governed by the Rgg2/3 Quorum Sensing System
Artemis Gogos, Michael J. Federle
Abstract
Streptococcus pyogenes is a human-restricted pathogen most often found in the human nasopharynx. Multiple bacterial factors are known to contribute to persistent colonization of this niche, and many are important in mucosal immunity and vaccine development. In this work, mice were infected intranasally with transcriptional regulator mutants of the Rgg2/3 quorum sensing (QS) system—a peptide-based signaling system conserved in sequenced isolates of S. pyogenes .
Topics & Concepts
BiologyStreptococcus pyogenesMicrobiologyQuorum sensingColonizationPathogenImmune systemImmunityRepressorRespiratory tractTranscriptional regulationBacteriaVirologyImmunologyGeneVirulenceTranscription factorGeneticsRespiratory systemStaphylococcus aureusAnatomyStreptococcal Infections and TreatmentsAntimicrobial Resistance in StaphylococcusOtolaryngology and Infectious Diseases