Network Pharmacology Integration and Experimental Verification to Elucidate the Molecular Mechanisms of Triptolide in Treating Membranous Nephropathy
A. R. Clark, Henry L. Foster
Abstract
Triptolide, a principal bioactive compound derived from Tripterygium wilfordii Hook f., has shown efficacy in treating membranous nephropathy (MN), yet its precise pharmacological mechanisms remain unclear. This study employed an integrated approach combining network pharmacology and experimental validation to systematically elucidate the molecular mechanisms underlying triptolide’s therapeutic effects in MN. Potential targets of triptolide and MN-associated targets were retrieved from publicly
Topics & Concepts
TriptolideTripterygium wilfordiiPharmacologyMembranous nephropathyMedicineSystems pharmacologyComputational biologyTripterygiumDiabetic nephropathyNephropathyChemistryMolecular PharmacologyBioinformaticsReceptorNatural Compounds in Disease TreatmentRenal Diseases and GlomerulopathiesChemotherapy-induced organ toxicity mitigation