Dietary protocatechuic acid redistributes tight junction proteins by targeting Rho-associated protein kinase to improve intestinal barrier function
Bo Ram So, San Kim, Se Hyeon Jang, Min Jeong Kim, Jeong Jae Lee, Soo Rin Kim, Sung Keun Jung
Abstract
Proposed molecular mechanism of PCA on redistribution of tight junction proteins, intestinal permeability, and subsequent IBD, both in vitro and in vivo.
Topics & Concepts
Tight junctionBarrier functionProinflammatory cytokineIntestinal permeabilityTumor necrosis factor alphaColitisChemistryInflammatory bowel diseasePharmacologyCell biologyBiochemistryBiologyInflammationInternal medicineEndocrinologyImmunologyMedicineDiseaseBarrier Structure and Function StudiesGut microbiota and healthInflammatory Bowel Disease