Role of the renal androgen receptor in sex differences in ammonia metabolism
Autumn N. Harris, Rebeca A. Castro, Hyun‐Wook Lee, Jill W. Verlander, I. David Weiner
Abstract
Sexual dimorphisms in ammonia metabolism involve androgen receptor (AR)-dependent signaling pathways in male, but not female, kidneys that lead to altered proximal tubule (PT), phosphoenolpyruvate carboxykinase, and thick ascending limb Na + -K + -2Cl − cotransporter expression. Adaptive responses in Na + /H + exchanger 3 and electrogenic Na + -bicarbonate cotransporter 1-A expression limit the magnitude of the effect on ammonia excretion. Finally, the greater kidney size and PT volume density in male mice is the result of PT androgen signaling through AR.
Topics & Concepts
Androgen receptorMetabolismAmmoniaChemistryEndocrinologyInternal medicineTestosterone (patch)BiochemistryBiologyMedicineProstate cancerCancerRenal function and acid-base balanceSodium Intake and HealthElectrolyte and hormonal disorders