β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease
Xia Zhao, Jinfeng Sun, Xiong Li, Lingyu She, Liwei Li, Hao Tang, Yuqing Zeng, Fan Chen, Xue Han, Shiju Ye, Wei Wang, Xu Wang, Guang Liang
Abstract
in microglial activation and AD pathology and provide a potential therapeutic strategy for neuroinflammation in AD.
Topics & Concepts
MicrogliaNeuroinflammationSykInflammationBiologyPathogenesisSignal transductionImmunologyReceptorAmyloid (mycology)Knockout mouseCell biologyNeuroscienceTyrosine kinaseBiochemistryBotanyNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsAdvanced Glycation End Products research