A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease
Prayasee Baruah, Hariharan Moorthy, Madhu Ramesh, Dikshaa Padhi, Thimmaiah Govindaraju
Abstract
the GPX4-ferroptosis axis. The ability of TA to enhance GPX4 levels under conditions of AD pathology opens up newer promising therapeutic avenues for combating the crosstalk between ferroptosis and AD.
Topics & Concepts
GPX4Reactive oxygen speciesOxidative stressChemistryProgrammed cell deathCell biologyLipid peroxidationAntioxidantBiochemistryApoptosisBiologyGlutathione peroxidaseCatalaseFerroptosis and cancer prognosisDrug Transport and Resistance MechanismsEpigenetics and DNA Methylation