Cancer-associated fibroblast spatial heterogeneity and <i>EMILIN1</i> expression in the tumor microenvironment modulate TGF-β activity and CD8<sup>+</sup> T-cell infiltration in breast cancer
Chikako Honda, Sasagu Kurozumi, Takaaki Fujii, Didier Pourquier, Lakhdar Khellaf, Florence Boissière‐Michot, Jun Horiguchi, Tetsunari Oyama, Ken Shirabe, Jacques Colinge, Takehiko Yokobori, Andrei Turtoï
Abstract
Our data show that correlating TGF-β signaling to a CAF subpopulation is not enough because proteins with TGF-β-modulating activity originating from other CAF subpopulations can alter its activity. Therefore, therapeutic targeting should remain focused on biological processes rather than on specific CAF subtypes.
Topics & Concepts
Breast cancerTumor microenvironmentCancer researchCD8CancerCytotoxic T cellTranscriptomeBiologyTransforming growth factor betaImmune systemGene expressionPathologyMedicineTransforming growth factorImmunologyInternal medicineGeneGeneticsIn vitroCancer Cells and MetastasisImmune cells in cancerSingle-cell and spatial transcriptomics