Metal-free electrochemical oxidative intramolecular cyclization of<i>N</i>-propargylbenzamides: facile access to oxazole ketals
Hua‐Xin Zhang, Yongge Xiong, Mu‐Jia Luo, Ruchun Yang, Jiang Bai, Xian‐Rong Song, Qiang Xiao
Abstract
An unprecedented and sustainable electrochemically driven oxidative 5- exo-dig radical cyclization of N -propargylbenzamides with alcohols for the synthesis of structurally diverse oxazole ketals is described.
Topics & Concepts
ChemistryOxazoleIntramolecular forceElectrochemistryOxidative phosphorylationCombinatorial chemistryMetalMedicinal chemistryStereochemistryOrganic chemistryElectrodeBiochemistryPhysical chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions