DCLK1 Regulates Tumor Stemness and Cisplatin Resistance in Non-small Cell Lung Cancer via ABCD-Member-4
Janani Panneerselvam, Priyanga Mohandoss, Ravi B. Patel, Hamza Gillan, Michael Li, Kirtana Kumar, DangHuy Nguyen, Nathaniel Weygant, Dongfeng Qu, Kamille Pitts, Stanley Lightfoot, Chinthalapally V. Rao, Courtney W. Houchen, Michael S. Bronze, Parthasarathy Chandrakesan
Abstract
using gene knockdown/knockout strategies alone or in combination with cisplatin may represent a novel therapeutic strategy to treat NSCLC.
Topics & Concepts
CisplatinCancer researchCancer stem cellClonogenic assayGene knockdownLung cancerGene silencingBiologyCancerAdenocarcinomaCancer cellCellCell cultureMedicineOncologyInternal medicineChemotherapyGeneGeneticsCancer Cells and MetastasisCancer Genomics and DiagnosticsHippo pathway signaling and YAP/TAZ